This study course provides in-depth knowledge on biomaterials and tissue biocompatibility and methodology of its assessment, to verify the safety of biomaterials and their interaction with biological environment. The study course is focused on obtaining the theoretical knowledge as well as elaborating the laboratory and practical tasks on evaluation of biomaterial and biological environment interactions. It also provides fundamental knowledge on biomaterial pre-clinical tests through using biological systems and model substances, including studies in simulated body fluids, in vitro cell studies and in vivo models. The study course will highlight the basic concepts of methodology used for biomaterial biocompatibility evaluation.